{"id":2682,"date":"2024-12-11T13:43:55","date_gmt":"2024-12-11T06:43:55","guid":{"rendered":"https:\/\/vpd.dfxh.shop\/?p=2682"},"modified":"2024-12-11T14:18:04","modified_gmt":"2024-12-11T07:18:04","slug":"ngay-the-gioi-phong-chong-aids-giai-quyet-thach-thuc-phat-hien-hiv","status":"publish","type":"post","link":"https:\/\/vanphucdang.com\/en\/world-aids-day-solves-hiv-detection-challenge\/","title":{"rendered":"World AIDS Day: Addressing the Challenge of HIV Detection"},"content":{"rendered":"

What is HIV and AIDS?<\/span>
\nHIV is a virus that specifically targets the immune system, weakening the body's ability to fight off infections and diseases, leaving the infected person vulnerable to opportunistic infections and certain cancers. The virus can be transmitted through certain body fluids such as blood, semen, vaginal fluids, and breast milk.<\/p>\n

AIDS is the advanced stage of HIV infection, occurring when the immune system is severely weakened, leaving the body vulnerable to opportunistic infections and certain cancers.[1]<\/p>\n

\"World<\/p>\n

HIV prevalence<\/span>
\nBy the end of 2023, an estimated 39.9 million people were living with HIV globally, and an estimated 42.3 million people had died from HIV\/AIDS-related complications. The African region is the most affected, with 1 in 30 adults (equivalent to approximately 3.41 TP3T) living with HIV, accounting for more than two-thirds of all people currently living with HIV worldwide.<\/p>\n

\"World<\/p>\n

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Challenges in HIV screening<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
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HIV can affect any individual, regardless of sexual orientation, race, ethnicity, gender, age, or geographic location. It is a major global health problem, characterized by a large number of infections and high mortality rates. The only way to definitively determine HIV status is through testing. However, public health systems around the world face significant challenges in accurately screening for HIV due to the risk of false positives.<\/p>\n

Solving the challenge<\/span>
\nTo address the challenges posed by current HIV screening and confirmation methods, it is necessary to find alternative methods that balance sensitivity, specificity, and cost-effectiveness. In this study, the researchers evaluated the performance of a new, cost-effective screening method, the Mindray CL-900i-HIV Ag\/Ab combo assay, as an alternative to the widely recognized ARCHITECT\u00ae HIV Ag\/Ab combo assay. In addition, they compared the performance of the Mindray CL-900i-HIV Ag\/Ab combo assay with the gold standard confirmation method, INNO-LIA\u2122 HIV I\/II. The evaluation also included an alternative reference method, PCR. The findings from this study are expected to provide valuable information to healthcare professionals to improve the efficiency of HIV screening procedures and diagnoses.<\/p>\n

The study analyzed retrospective data from a large cohort of individuals screened for HIV at MC during 2022\u20132023 using the Architect-HIV assay. From this dataset, 195 samples were selected based on the similarities and differences between the ARCHITECT\u00ae HIV Ag\/Ab combo assay and the gold standard confirmatory assay INNO-LIA\u2122 HIV I\/II. These samples included: positive cases by both methods, positive cases by the ARCHITECT\u00ae method only, indeterminate cases, and negative cases by both methods. All selected samples underwent retesting using the Mindray CL-900i-HIV Ag\/Ab combo assay, with positive results from the ARCHITECT\u00ae method further confirmed by PCR. This rigorous process comprehensively evaluated the accuracy of the Mindray CL-900i-HIV assay, focusing specifically on potentially false-positive samples, thereby providing strong evidence of its efficacy and feasibility as an alternative screening method.<\/p>\n

 <\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n\n\n\n\n
Table 1. Comparison of Mindray CL-900i-HIV Ag\/Ab combo results with INNO-LIA\u2122 HIVI\/II confirmatory assay.<\/caption>\n
\n

 <\/p>\n<\/th>\n

INNO-LIA-HIV+<\/th>\nINNO-LIA-HIV-<\/th>\nINNO-LIA-HIV IND<\/th>\nTotal<\/th>\n<\/tr>\n<\/thead>\n
CL-900i-HIV+<\/b><\/td>\n38 (20.5%)<\/td>\n0 (0%)<\/td>\n5 (2.7%)<\/td>\n43 (23.2%)<\/td>\n<\/tr>\n
CL-900i-HIV-<\/b><\/td>\n0 (0%)<\/td>\n121 (65.4%)<\/td>\n21 (11.4%)<\/td>\n142 (76.8%)<\/td>\n<\/tr>\n
Total<\/b><\/td>\n38 (20.5%)<\/td>\n21 (65.4%)<\/td>\n26 (14.1%)<\/td>\n185 (100%)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Table 2. Concordance assessment between Mindray CL-900i-HIV Ag\/Ab combo in comparison to INNOLIA\u2122 HIVI\/II (n = 159).<\/caption>\n
Performance parameters<\/th>\n\u00a0<\/th>\n<\/tr>\n<\/thead>\n
Sensitivity (%)<\/td>\n100% (90.7-100)<\/td>\n<\/tr>\n
Specificity (%)<\/td>\n100% (97.0-100)<\/td>\n<\/tr>\n
PPV (%)<\/td>\n100% (90.7-100)<\/td>\n<\/tr>\n
NPV (%)<\/td>\n100% (97.0-100)<\/td>\n<\/tr>\n
OPA (%)<\/td>\n100% (97.7-100)<\/td>\n<\/tr>\n
PPA (%)<\/td>\n100% (90.7-100)<\/td>\n<\/tr>\n
NPA (%)<\/td>\n100% (97.0-100)<\/td>\n<\/tr>\n
Efficiency\/accuracy (%)<\/td>\n100% (97.7-100)<\/td>\n<\/tr>\n
Cohen's Kappa coefficient<\/td>\n1.00 (1.00-1.00)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\"World<\/p>\n

The Mindray CL-900i-HIV Ag\/Ab combo assay is a two-site CLIA sandwich assay. It uses monoclonal antibodies and HIV-1 or HIV-2 antigens coated on microparticles, allowing simultaneous testing of both antigens and antibodies associated with HIV infection. The procedure involves combining the sample with assay diluent and magnetic microparticles coated with HIV antigens and antibodies, then performing a chemiluminescence reaction and measuring the emitted light as relative light units (RLUs). This method demonstrated high sensitivity and specificity compared to the gold standard confirmatory method INNO-LIA\u2122 HIV I\/II, with no false positives noted.<\/strong><\/p>\n

References:<\/b><\/p>\n

[1]. What Are HIV and AIDS? HIV. Gov. available from: What Are HIV and AIDS? | HIV.gov<\/p>\n

[2]. HIV. The Global Health Observatory. World Health Organization. 2024.<\/p>\n

Source:<\/strong> https:\/\/www.mindray.com\/<\/p>","protected":false},"excerpt":{"rendered":"

What are HIV and AIDS? HIV is a virus that specifically targets the immune system, weakening the body's ability to fight infections and diseases, leaving infected people vulnerable to opportunistic infections and certain cancers. The virus [\u2026]<\/p>","protected":false},"author":1,"featured_media":2683,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[235,110],"tags":[],"class_list":["post-2682","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cong-dong","category-tin-tuc"],"yoast_head":"\nNg\u00e0y Th\u1ebf Gi\u1edbi Ph\u00f2ng Ch\u1ed1ng AIDS: Gi\u1ea3i Quy\u1ebft Th\u00e1ch Th\u1ee9c Ph\u00e1t Hi\u1ec7n HIV - V\u1ea1n Ph\u00fac \u0110\u0103ng<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/vanphucdang.com\/en\/world-aids-day-solves-hiv-detection-challenge\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ng\u00e0y Th\u1ebf Gi\u1edbi Ph\u00f2ng Ch\u1ed1ng AIDS: Gi\u1ea3i Quy\u1ebft Th\u00e1ch Th\u1ee9c Ph\u00e1t Hi\u1ec7n HIV\" \/>\n<meta property=\"og:description\" content=\"HIV v\u00e0 AIDS l\u00e0 g\u00ec? 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HIV l\u00e0 m\u1ed9t lo\u1ea1i virus nh\u1eafm m\u1ee5c ti\u00eau c\u1ee5 th\u1ec3 v\u00e0o h\u1ec7 mi\u1ec5n d\u1ecbch, l\u00e0m suy y\u1ebfu kh\u1ea3 n\u0103ng ch\u1ed1ng l\u1ea1i c\u00e1c b\u1ec7nh nhi\u1ec5m tr\u00f9ng v\u00e0 b\u1ec7nh t\u1eadt c\u1ee7a c\u01a1 th\u1ec3, khi\u1ebfn ng\u01b0\u1eddi nhi\u1ec5m d\u1ec5 b\u1ecb m\u1eafc c\u00e1c b\u1ec7nh nhi\u1ec5m tr\u00f9ng c\u01a1 h\u1ed9i v\u00e0 m\u1ed9t s\u1ed1 lo\u1ea1i ung th\u01b0. Virus […]","og_url":"https:\/\/vanphucdang.com\/en\/world-aids-day-solves-hiv-detection-challenge\/","og_site_name":"V\u1ea1n Ph\u00fac \u0110\u0103ng","article_published_time":"2024-12-11T06:43:55+00:00","article_modified_time":"2024-12-11T07:18:04+00:00","og_image":[{"width":319,"height":202,"url":"https:\/\/vanphucdang.com\/wp-content\/uploads\/2024\/12\/world-aids-day-addressing-hiv-detection-challenge.thumb_.319.319.png","type":"image\/png"}],"author":"Admin","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Admin","Est. reading time":"7 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/vanphucdang.com\/ngay-the-gioi-phong-chong-aids-giai-quyet-thach-thuc-phat-hien-hiv\/#article","isPartOf":{"@id":"https:\/\/vanphucdang.com\/ngay-the-gioi-phong-chong-aids-giai-quyet-thach-thuc-phat-hien-hiv\/"},"author":{"name":"Admin","@id":"https:\/\/vanphucdang.com\/#\/schema\/person\/2f552b062ca447c44514fc14a77a0912"},"headline":"Ng\u00e0y Th\u1ebf Gi\u1edbi Ph\u00f2ng Ch\u1ed1ng AIDS: Gi\u1ea3i Quy\u1ebft Th\u00e1ch Th\u1ee9c Ph\u00e1t Hi\u1ec7n HIV","datePublished":"2024-12-11T06:43:55+00:00","dateModified":"2024-12-11T07:18:04+00:00","mainEntityOfPage":{"@id":"https:\/\/vanphucdang.com\/ngay-the-gioi-phong-chong-aids-giai-quyet-thach-thuc-phat-hien-hiv\/"},"wordCount":1408,"commentCount":0,"publisher":{"@id":"https:\/\/vanphucdang.com\/#organization"},"image":{"@id":"https:\/\/vanphucdang.com\/ngay-the-gioi-phong-chong-aids-giai-quyet-thach-thuc-phat-hien-hiv\/#primaryimage"},"thumbnailUrl":"https:\/\/vanphucdang.com\/wp-content\/uploads\/2024\/12\/world-aids-day-addressing-hiv-detection-challenge.thumb_.319.319.png","articleSection":["C\u1ed9ng \u0111\u1ed3ng","Tin t\u1ee9c"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/vanphucdang.com\/ngay-the-gioi-phong-chong-aids-giai-quyet-thach-thuc-phat-hien-hiv\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/vanphucdang.com\/ngay-the-gioi-phong-chong-aids-giai-quyet-thach-thuc-phat-hien-hiv\/","url":"https:\/\/vanphucdang.com\/ngay-the-gioi-phong-chong-aids-giai-quyet-thach-thuc-phat-hien-hiv\/","name":"Ng\u00e0y Th\u1ebf Gi\u1edbi Ph\u00f2ng Ch\u1ed1ng AIDS: Gi\u1ea3i Quy\u1ebft Th\u00e1ch Th\u1ee9c Ph\u00e1t Hi\u1ec7n HIV - 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